分子夾雑の生命化学

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公募班メンバーの紹介

公募班の先生方には「分子夾雑の生命化学」を推進する上で、計画班メンバーだけでは不足する研究分野を補い、領域研究体制を一層発展的なものにする役割を期待しています。参考までに想定されるキーワードを含めた図を示しますが、これだけに限定されるわけではありません。創造的かつ世界トップレベルの「分子夾雑の生命化学」研究に関する研究提案を幅広く募集いたします。また、本領域総括班が運営するCIBIC(統合生命化学研究センター)にも、公募班メンバーの積極的な関与を歓迎します。ぜひ、計画班と一体になった分野横断的共同研究を推進に貢献ください。

公募班メンバーの紹介

A01:Chemistry for Multi-molecular Crowding Biosystems

Tomonao Inobe

Graduate School of Science and Engineering, University of Toyama, Associate Professor

Artificial regulation of selective protein degradation in cellular crowding systems

Takeaki Ozawa
Wataru Kakegawa 

Department of Physiology, Keio University School of Medicine, Associate Professor

A Novel Chemogenetic Tool Which Regulates Neuronal Circuits for Learning and Memory

Toru Komatsu

Graduate School of Pharmaceutical Sciences, The University of Tokyo,  Assistant Professor

Development of on-organelle protein trapping method to study the meanings of transient organelle localization of tumor-associated proteins

Kazuki Tainaka

Brain Research Institute, Niigata University, Specially Appointed Professor

Design Strategy of Chemical Probes for Cleared Tissue Samples

Shinya Tsukiji 

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Professor 

Development and application of synthetic molecules that recognize intracellular organelle membranes

Takuya Terai 

Graduate School of Science and Engineering, Saitama University, Research Associate 

Development of in Vitro Evolutionary System of Peptide Ligands That Work in Heterogenous Environment

Hiroyuki Nakamura

Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Professor

Development of Photcatalyst-Based Proximity Labeling in Complex Protein Envioronment

Shiroh Futaki 

Institute for Chemical Research, Kyoto University, Professor 

Functional Peptides Inducing Membrane Curvatures and Altering Lipid Packing States

Tatsuo Maruyama

Graduate School of Engineering, Kobe University, Associate Professor

Fate control of cancer cells uisng the intracellular self-assembly of synthetic lipids

Kenzo Yamatsugu

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Assistant Professor 

Chemical Catalyst Systems Regulating Cellular Functions through Synthetic Histone Acylation

A02:分子夾雑の物理・計算化学

Satoko Akashi

Graduate School of Medical Life Science, Yokohama City University, Associate Professor

Native Mass Spectrometry for Characterization of Protein Iinteractions under Crowded Conditions

Koichiro Ishimori

Faculty of Science, Hokkaido University, Professor

Pressure Effects on Protein Structure and Function in Multimolecular Crowding System

Takumi Ueda

Graduate School of Pharmaceutical Sciences, The University of Tokyo,  Research Associate

Structural Elucidation of the Fuctions of G Protein-Coupled Receptor Under the Macromolecular Crowding Byosystems Using Nuclear Magnetic Resonance Spectroscopy

Hiroyuki Oikawa

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Assistant Professor

Tracking of protein conformational changes in crowded environments by using single-molecule fluorescence spectroscopy

Masato Katahira 

Institute of Advanced Energy, Kyoto University, Professor

Structure and Interaction of Nucleic Acids in Molecularly Crowded Environment of Living Human Cells 

Yasushi Kawata

Graduate School of Engineering, Tottori University, Professor

In vivo and in vitro aggregation analysis and its control of intrinsically disordered alpha-synuclein protein

Isao Kii 

Institute of Agriculture, Shinshu University, 
Associate Professor

Drug Discovery Targeting Actual Behavior of Kinase Hidden in Cellular Molecular Crowding Condition

Kaoru Sato 

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Assistant Professor

Elucidating the molecular mechanims of Nuage formation and piRNA biogenesis in Drosophila germline

Kenji Sugase 

Graduate School of Engineering, Kyoto University, Associate Professor

Elucidating the Influence of Crowding Effect and Shear Force on Protein Stability Using Rheo-NMR

Yusuke Nakasone 

Graduate School of Science, Kyoto University, Assistant Professor 

Dynamic Behavior of Proteins in Crowding Environment -Fluctuations and Reaction Dynamics-

Kei Fujiwara 

Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Assistant Professor

A constructive approach to elucidate dynamic transitions of biosystems caused by multimolecular environments

Yoshiaki Furukawa

Department of Chemistry, Keio University, Associate Professor

A mechanism for metal acquisition of proteins in a crowded environment 

kazunori Matsuura

Graduate School of Engineering, Tottori University, Professor

Physical Chemistry for Self-assembly of Viral Capsids in Molecular Crowding System

A03:分子夾雑の分析・応用化学

Satoshi Arai 

Research Institute for Science and Engineering, Waseda University, Assistant Professor

Development of Temperature Control System at Subcellular Level Using Photothermal Agents

Yasuo Uchida 

Graduate School of Pharmaceutical Sciences, Tohoku University, Lecturer

Investigation of drug transport system at the human blood-brain barrier based on the reconstruction of multimolecular crowding transport system

Susumu Uchiyama 

Graduate School of Engineering, Osaka University, Professor

Quantitative analysis of intermolecular interaction under multi-components environments using analytical ultracentrifugation with fluorescence detection system

Yoichi Otsuka 

Graduate School of Science, Osaka University, Assistant Professor 

Visualization of Multimolecular Crowding Biological Information by Ideal Imaging Mass Spectrometry with Nanovolume Liquid

Noritada Kaji 

Graduate School of Engineering, Department of Applied Chemistry, Kyushu University, Professor

Development of Quantitative Analytical Methods for Molecular Crowding Conditions Using Enzyme Assay

Kyosuke Shinohara 

Department of Biotechnology & Life Science, Tokyo University of Agriculture & Technology, Associate Professor

Characterization of nature of Hsp104 disaggregase in crowding system and its application to therapy for neurodegenerative diseases

Nobuaki Takemori 

Instutute for the Promotion of Science and Technology, Ehime University, Lecturer

Structural analysis of proteins in a multimolecular crowding environment by top-down proteomics

Public Offered Research